ChloroquineV1, Main, Exploration, bibRecord, 001C20

Metal-based antitumour drugs in the post genomic era

Identifieur interne : 001C20 ( Main/Exploration ); précédent : 001C19; suivant : 001C21

Metal-based antitumour drugs in the post genomic era

Auteurs : Paul J. Dyson [Suisse] ; Gianni Sava [Italie]

Source :

Dalton Transactions [ 1477-9226 ] ; 2006.

RBID : ISTEX:F1230AE13BA166A34534773FA81C2FD98CE43458

English descriptors

Teeft :
- Alessio, Anticancer drugs, Bergamo, Callerio foundation onlus, Cell lines, Cell membrane, Chem, Cisplatin, Clinical trials, Cocchietto, Dalton trans, Drug resistance, Drug targets, Dyson, Endothelial cells, General toxicity, Ligand, Medicinal chemistry, Metastasis, Metastasis tumours, Organic compounds, Organometallic, Physiological environment, Plasma proteins, Post genomic, Primary tumours, Protein targets, Rapta compounds, Recent study, Royal society, Sava, Toxicity, Tumour, Tumour cells, Tumour malignancy.

Abstract

The discovery of new metal-based antitumour drugs, whether cisplatin derivatives or those based on other metals, has been largely based on cell viability assays (IC50 values) and compounds that bind to DNA. This approach has been applied for more than 30 years during which time very few new drugs have entered clinical use. In this article we discuss what the future holds for metal-based drugs, in particular anti-metastasis drugs, in these enlightened times of the post genomic era.

Url:

https://api.istex.fr/ark:/67375/QHD-RHM3MWL0-Q/fulltext.pdf

DOI: 10.1039/b601840h

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001463
to stream Istex, to step Curation: 001463
to stream Istex, to step Checkpoint: 000A88
to stream Main, to step Merge: 001C32
to stream Main, to step Curation: 001C20

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Metal-based antitumour drugs in the post genomic era</title>
<author wicri:is="90%"><name sortKey="Dyson, Paul J" sort="Dyson, Paul J" uniqKey="Dyson P" first="Paul J." last="Dyson">Paul J. Dyson</name>
</author>
<author wicri:is="90%"><name sortKey="Sava, Gianni" sort="Sava, Gianni" uniqKey="Sava G" first="Gianni" last="Sava">Gianni Sava</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F1230AE13BA166A34534773FA81C2FD98CE43458</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1039/b601840h</idno>
<idno type="url">https://api.istex.fr/ark:/67375/QHD-RHM3MWL0-Q/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001463</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001463</idno>
<idno type="wicri:Area/Istex/Curation">001463</idno>
<idno type="wicri:Area/Istex/Checkpoint">000A88</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000A88</idno>
<idno type="wicri:doubleKey">1477-9226:2006:Dyson P:metal:based:antitumour</idno>
<idno type="wicri:Area/Main/Merge">001C32</idno>
<idno type="wicri:Area/Main/Curation">001C20</idno>
<idno type="wicri:Area/Main/Exploration">001C20</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Metal-based antitumour drugs in the post genomic era</title>
<author wicri:is="90%"><name sortKey="Dyson, Paul J" sort="Dyson, Paul J" uniqKey="Dyson P" first="Paul J." last="Dyson">Paul J. Dyson</name>
<affiliation wicri:level="3"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Suisse</country>
</affiliation>
</author>
<author wicri:is="90%"><name sortKey="Sava, Gianni" sort="Sava, Gianni" uniqKey="Sava G" first="Gianni" last="Sava">Gianni Sava</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Callerio Foundation Onlus, 34127, Via A. Fleming 22-31, Trieste</wicri:regionArea>
<wicri:noRegion>Trieste</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Biomediche, Università di Trieste, 34127, Via L. Giorgieri 7-9, Trieste</wicri:regionArea>
<wicri:noRegion>Trieste</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Italie</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Dalton Transactions</title>
<title level="j" type="abbrev">Dalton Trans.</title>
<idno type="ISSN">1477-9226</idno>
<idno type="eISSN">1477-9234</idno>
<imprint><publisher>The Royal Society of Chemistry.</publisher>
<date type="published" when="2006">2006</date>
<biblScope unit="volume">0</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="1929">1929</biblScope>
<biblScope unit="page" to="1933">1933</biblScope>
</imprint>
<idno type="ISSN">1477-9226</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1477-9226</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alessio</term>
<term>Anticancer drugs</term>
<term>Bergamo</term>
<term>Callerio foundation onlus</term>
<term>Cell lines</term>
<term>Cell membrane</term>
<term>Chem</term>
<term>Cisplatin</term>
<term>Clinical trials</term>
<term>Cocchietto</term>
<term>Dalton trans</term>
<term>Drug resistance</term>
<term>Drug targets</term>
<term>Dyson</term>
<term>Endothelial cells</term>
<term>General toxicity</term>
<term>Ligand</term>
<term>Medicinal chemistry</term>
<term>Metastasis</term>
<term>Metastasis tumours</term>
<term>Organic compounds</term>
<term>Organometallic</term>
<term>Physiological environment</term>
<term>Plasma proteins</term>
<term>Post genomic</term>
<term>Primary tumours</term>
<term>Protein targets</term>
<term>Rapta compounds</term>
<term>Recent study</term>
<term>Royal society</term>
<term>Sava</term>
<term>Toxicity</term>
<term>Tumour</term>
<term>Tumour cells</term>
<term>Tumour malignancy</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">The discovery of new metal-based antitumour drugs, whether cisplatin derivatives or those based on other metals, has been largely based on cell viability assays (IC50 values) and compounds that bind to DNA. This approach has been applied for more than 30 years during which time very few new drugs have entered clinical use. In this article we discuss what the future holds for metal-based drugs, in particular anti-metastasis drugs, in these enlightened times of the post genomic era.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
<li>Suisse</li>
</country>
<region><li>Canton de Vaud</li>
</region>
<settlement><li>Lausanne</li>
</settlement>
</list>
<tree><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Dyson, Paul J" sort="Dyson, Paul J" uniqKey="Dyson P" first="Paul J." last="Dyson">Paul J. Dyson</name>
</region>
<name sortKey="Dyson, Paul J" sort="Dyson, Paul J" uniqKey="Dyson P" first="Paul J." last="Dyson">Paul J. Dyson</name>
</country>
<country name="Italie"><noRegion><name sortKey="Sava, Gianni" sort="Sava, Gianni" uniqKey="Sava G" first="Gianni" last="Sava">Gianni Sava</name>
</noRegion>
<name sortKey="Sava, Gianni" sort="Sava, Gianni" uniqKey="Sava G" first="Gianni" last="Sava">Gianni Sava</name>
<name sortKey="Sava, Gianni" sort="Sava, Gianni" uniqKey="Sava G" first="Gianni" last="Sava">Gianni Sava</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C20 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C20 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:F1230AE13BA166A34534773FA81C2FD98CE43458
   |texte=   Metal-based antitumour drugs in the post genomic era
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Metal-based antitumour drugs in the post genomic era

Metal-based antitumour drugs in the post genomic era

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri